HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorophenyl Isocyanate → 1-{3-[4-(4-Chlorobenzyl)piperazin-1-yl]propyl}-3-(4-chlorophenyl)urea hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorophenyl Isocyanate | HCID 7693 | — |
| Reactant | HCID 13606667 | HCID 13606667 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-{3-[4-(4-Chlorobenzyl)piperazin-1-yl]propyl}-3-(4-chlorophenyl)urea hydrochloride | HCID 13606680 | 48.1% |
Reaction Steps
The procedure described in Example 3 was followed, using 1-(3-aminopropyl)-4-(4-chlorobenzyl)piperazine (2.67 g; 10 mmole), methylene chloride (50 ml) and 4-chlorophenyl isocyanate (1.54 g; 10 mmole). Recrystallization from methanol provided the title compound (1.1 g; 25% yield) as colorless crystals, m.p. 241° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04661481 |
| Source dataset | uspto-grants-1987_04 |
| ORD ID | ord-0a5617244d0f456caef189b7cbc5160e |
| Source note | uspto-grants-1987_04 |