HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Isocyanato-4-methoxybenzene → 1-{3-[4-(4-Chlorobenzyl)piperazin-1-yl]-propyl}-3-(4-methoxyphenyl)urea hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Isocyanato-4-methoxybenzene | HCID 79443 | — |
| Reactant | HCID 13606667 | HCID 13606667 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-{3-[4-(4-Chlorobenzyl)piperazin-1-yl]-propyl}-3-(4-methoxyphenyl)urea hydrochloride | HCID 13606684 | 82.9% |
Reaction Steps
The procedure described in Example 3 was followed, using 1-(3-aminopropyl)-4-(4-chlorobenzyl)piperazine (5.09 g; 19 mmole), methylene chloride (50 ml) and 4-methoxyphenyl isocyanate (2.83 g; 19 mmole). Recrystallization from methanol/methylene chloride provided the title compound (3.57 g; 45% yield) as orange-white crystals, m.p. 237°-238° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04661481 |
| Source dataset | uspto-grants-1987_04 |
| ORD ID | ord-9a72fc3f4ed6425b9a83eec8cf992cdf |
| Source note | uspto-grants-1987_04 |