Ethyl 6-oxoheptanoate → HCID 21294057, compound

HRID 543219Notes

Reaction equation

HRID 543219 reaction equation
O=[C:2]([CH3:12])[CH2:3][CH2:4][CH2:5][CH2:6][C:7]([O:9]CC)=[O:8].BrC(C)CCCCC(OCC)=O.[CH3:25][CH2:26][CH2:27][C:28]1[C:33]([OH:34])=[C:32]([C:35]([CH3:37])=[O:36])[CH:31]=[CH:30][C:29]=1[OH:38]>>[C:35]([C:32]1[CH:31]=[CH:30][C:29]([O:38][CH:2]([CH3:12])[CH2:3][CH2:4][CH2:5][CH2:6][C:7]([OH:9])=[O:8])=[C:28]([CH2:27][CH2:26][CH3:25])[C:33]=1[OH:34])(=[O:36])[CH3:37]

Participants

4

Reactant 3

HCID 539116Ethyl 6-oxoheptanoateHCID 27751982',4'-Dihydroxy-3'-propylacetophenoneHCID 12939997Heptanoic acid, 6-bromo-, ethyl ester2×

Product 1

HCID 21294057HCID 21294057, compound

Procedure

Following the procedure of Example 15, ethyl 6-oxo-heptanoate was transformed into ethyl 6-bromo-heptanoate. The reaction of 4.74 g. of ethyl 6-bromoheptanoate and 3.88 g. of 2,4-dihydroxy-3-propylacetophenone followed by hydrolysis in the usual manner gave 300 mg. of the title product as an oil.

Workup

  1. customThe reaction of 4.74 g
  2. customgave 300 mg

Sources & evidence

ORD record
ord-ce20cce9862342e08aa1f5021a74c775
Source dataset
uspto-grants-1987_04
Patent number
US04661505

Reaction notes

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