HuagongsheHuagongshe Chemistry Print Report · For research reference only
Amantadine → HCID 86741458, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Amantadine | HCID 2130 | — |
| Reactant | L-Pyroglutamic Acid | HCID 7405 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Pivaloyl chloride | HCID 62493 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 86741458 | HCID 86741458 | — |
Reaction Steps
10 g of (L)-pyroglutamic acid (77 mmol) and 10.7 ml of triethylamine are mixed with 100 ml of anhydrous acetone, 9.29 g of pivaloyl chloride (77 mmol) are run in slowly at -5° and then, after 15 minutes at 0° C., 11.65 g (77 mmol) of adamantanamine are added in several portions.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04661512 |
| Source dataset | uspto-grants-1987_04 |
| ORD ID | ord-cb5f284428f141e4b57c51f89a71caba |
| Source note | uspto-grants-1987_04 |