HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → benzyl N-[2-ethylhexanoyl]-(L)-pyroglutamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Ethylhexanoyl chloride | HCID 79103 | — |
| Reactant | Benzyl 5-oxoprolinate | HCID 2381219 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | benzyl N-[2-ethylhexanoyl]-(L)-pyroglutamate | HCID 13655558 | — |
Reaction Steps
39.4 g (180 mmol) of benzyl (L)-pyroglutamate, prepared according to Example II(1), are dissolved in 160 ml of chloroform and 28.4 g (28 mmol) of triethylamine at ordinary temperature. A solution of 29.3 g (180 mmol) of 2-ethylhexanoyl chloride in 40 ml of chloroform is run in and the mixture is heated under reflux for 5 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04661512 |
| Source dataset | uspto-grants-1987_04 |
| ORD ID | ord-f480a0d847784f09859cad69f5e1b07d |
| Source note | uspto-grants-1987_04 |