Water → HCID 54263403, compound

Participants

Reaction Conditions

Reaction Steps

To 5 ml of anhydrous dimethyl cellosolve was added 0.1 g of 60% sodium hydride, and thereinto 0.9 g of diethyl 3-benzoylbenzylphosphonate (prepared according to (1) of Synthesic Example 11) was added dropwise, and the mixture was stirred at 50° C. for 30 minutes. Then, a solution of 0.6 g of 3-(3-bromo-4-ethoxyphenyl)-3-methylbutanal in 2 ml of dimethyl cellosolve was added dropwise into the mixture, and stirred at 80° C. for one hour. After cooling, the reaction mixture was poured into water and extracted with benzene, and the benzene extract was washed with water and dried, and evaporated under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: benzene) to give 0.7 g of the desired product.

Provenance & Evidence