関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | 1-Isoquinolinamine | HCID 73742 | — |
| 反応物 | 3-Dimethylaminomethylenedihydrofuran-2-one | HCID 304566 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 3-(2-hydroxyethyl)-4H-pyrimido[2,1-a]isoquinolin-4-one | HCID 13851103 | 75% |
反応手順
A heterogenous mixture containing 14.4 g of 1-isoquinolinamine (0.1 m) and 14.12 g of dihydro-3-[(dimethylamino)methylene]-2(3H)-furanone was heated to 200° C. for 4 hours to yield a homogenous yellow orange solution which solidified upon cooling to ambient temperature. The solidified reaction mixture was titurated with methanol and ethyl acetate to yield 3-(2-hydroxyethyl)-4H-pyrimido[2,1-a]isoquinolin-4-one as a tan solid (18.0 g; 75% yield) of the formula ##STR26## having a melting point of 185.2°-187.0° C. and the following elemental analysis:
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04661592 |
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| 出典データセット | uspto-grants-1987_04 |
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| ORD ID | ord-11ce99d2bcff44c49a98231153e41a2f |
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| 出典メモ | uspto-grants-1987_04 |
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