3,4-Dimethoxybenzeneacetonitrile → Veratrole

HRID 543315Notes

Reaction equation

HRID 543315 reaction equation
C(C#N)[C:2]1[CH:11]=[CH:10][C:7]([O:8][CH3:9])=[C:4]([O:5][CH3:6])[CH:3]=1.C(Cl)C1C=CC(OC)=C(OC)C=1>C1(C)C=CC=CC=1>[C:7]1([O:8][CH3:9])[C:4](=[CH:3][CH:2]=[CH:11][CH:10]=1)[O:5][CH3:6]

Participants

4

Reactant 2

HCID 667273,4-DimethoxybenzeneacetonitrileHCID 81740Veratryl chloride

Product 1

HCID 7043Veratrole

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The present invention relates to a process for the preparation of veratryl cyanide (VCN), wherein the toluene solution of the veratryl chloride obtained by chloromethylation of veratrol is reacted directly with sodium cyanide, with the addition of water, a ketone and a catalyst.

Sources & evidence

ORD record
ord-b047ddeb84414351aab204bbcc981fb5
Source dataset
uspto-grants-1987_04
Patent number
US04661610

Reaction notes

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