HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Trans-2-[(3,5-bistrifluoromethyl phenyl)-aminocarbonyl]-cyclobutane carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Cis-2-[(3,5-bistrifluoromethyl phenyl)-aminocarbonyl]-cyclobutane carboxylic acid | HCID 18607497 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | Trans-2-[(3,5-bistrifluoromethyl phenyl)-aminocarbonyl]-cyclobutane carboxylic acid | HCID 13376256 | 68% |
Reaction Steps
5.0 g of cis-2-[(3,5-bistrifluoromethyl phenyl)-aminocarbonyl]-cyclobutane carboxylic acid was reacted at a temperature of 50° C. for three hours in 10% aqueous caustic soda solution. The products were neutralized with dilute hydrochloric acid, extracted with ethyl acetate and then recrystallized from acetonitrile to give 3.4 g of the title compounds (yield: 68%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04661630 |
| Source dataset | uspto-grants-1987_04 |
| ORD ID | ord-a3c3610774a2403691a5e8fbac39d2fc |
| Source note | uspto-grants-1987_04 |