Dichloroacetic Acid → 4-tert-Butyl-2-(chloromethanesulfonyl)-1-methoxybenzene

Participants

Reaction Steps

22.8 g (0.1 mol) of 3-(1,1-dimethylethyl)-2-methoxybenzenesulfinic acid, 23 g of Na2CO3 and 15 g (0.117 mol) of dichloroacetic acid are dissolved in 150 ml of H2. The solution is slowly evaporated to dryness at a bath temperature of 160° C. The residue is again taken up in H2O, and the solution is neutralized with a little dilute hydrochloric acid and extracted by shaking several times with ethyl acetate. After removing the solvent, the product is obtained as crystals.

Provenance & Evidence