反应详情

12.3 g (0.075 mol) of 4-(1,1-dimethylethyl)anisole, dissolved in 30 ml of methylene chloride, are added dropwise, while cooling in ice, to 16.5 ml of chlorosulfonic acid dissolved in 20 ml of methylene chloride. The mixture is stirred for 40 minutes and then poured onto ice-water. The organic phase is separated off, washed with water, dried with MgSO4 and evaporated. Recrystallization from toluene/petroleum ether provides crystals of melting point: 75°-77° C.

1. additionare added dropwise
2. additionpoured onto ice-water
3. customThe organic phase is separated off
4. washwashed with water
5. dry with materialdried with MgSO4
6. customevaporated
7. customRecrystallization from toluene/petroleum ether
8. customprovides crystals of melting point: 75°-77° C.