Hydrochloric Acid → HCID 13669832, compound

Participants

Reaction Steps

A mixture of 1.5 g of 8-fluoro-3-hydroxy-4-methyl9-oxo-9H-xanthene, 3.0 g of potassium carbonate, 3.6 g of ethyl bromoacetate and 40 ml of DMF was stirred at 60°-70° C. for 2 hours. After cooling the mixture, sodium hydroxide (3 g) and water (40 ml) were added and the resulting mixture was stirred at 90°-100° C. for 30 minutes. After cooling, the mixture was rendered acidic with hydrochloric acid and the solid crystal was recovered by filtration, washed with water and dried. Recrystallization from DMF gave 1.4 g of 8-fluoro-4-methyl-9-oxo-9H-xanthene-3-yloxyacetic acid. m.p. 259°-261° C. This compound showed a mass spectrum having a molecular ion peak at m/e 302.

Provenance & Evidence