Hydrochloric Acid → HCID 13669845, compound

Participants

Reaction Steps

A mixture of 2-hydroxy-3-methyl-9-oxo-9H-xanthene (1.1 g), potassium carbonate (1.4 g), ethyl bromoacetate (1.7 g) and DMF (20 ml) was stirred at 60°-70° C. for 3 hours. After cooling the mixture, sodium hydroxide (4 g) and water (100 ml) were added and the resulting mixture was stirred at 90°-100° C. for 1 hour. After cooling, the mixture was rendered acidic with hydrochloric acid and the solid crystal was recovered by filtration, washed with water and dried. Recrystallization from DMF gave 1.3 g of 3-methyl-9-oxo-9H-xanthene-2-yloxyacetic acid. m.p. 225°-227° C. This compound showed a mass spectrum having a molecular ion peak at m/e 284.

Provenance & Evidence