Hydrochloric Acid → HCID 21268854, compound

Participants

Reaction Steps

A mixture of 2,4-dichloro-3-hydroxy-9-oxo-9H-xanthene (7.5 g), potassium carbonate (7.5 g), ethyl bromoacetate (9.0 g) and DMF (100 ml) was stirred at 55°-65° C. for 3 hours. After cooling the mixture, sodium hydroxide (20 g) and water (250 ml) were added and the resulting mixture was stirred at 90°-100° C. for 1 hour. After cooling, the mixture was rendered acidic with hydrochloric acid and the solid crystal was recovered by filtration, washed with water and dried. Recrystallization from ethanol gave 4.0 g of 2,4-dichloro-9-oxo-9H-xanthene-3-yloxyacetic acid. m.p. 225°-228° C. This compound gave a mass spectrum having a molecular ion peak at m/e 338.

Provenance & Evidence