Hydrochloric Acid → HCID 21268855, compound

Participants

Reaction Steps

A mixture of 3-hydroxy-2-methyl-9-oxo-9H-xanthene (1.8 g), potassium carbonate (2.2 g), ethyl bromoacetate (2.7 g) and DMF (40 ml) was stirred at 60°-70° C. for 2 hours. After cooling the mixture, sodium hydroxide (3.2 g) and water (40 ml) were added and the resulting mixture was stirred at 90°-100° C. for 1 hour. After cooling, the mixture was rendered acidic with hydrochloric acid and the solid crystal was recovered by filtration, washed with water and dried. Recrystallization from ethanol gave 1.8 g of 2-methyl-9-oxo-9H-xanthene-3-yloxyacetic acid. m.p. 236°-238° C. This compound showed a mass spectrum having a molecular ion peak at m/e 284.

Provenance & Evidence