Hydrochloric Acid → N,N-Diethyl-4-phenylpiperazine-1-carboxamide--hydrogen chloride (1/1)

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Reaction Steps

In 50 ml of chloroform was dissolved 2.6 g (0.01 mole) of 1-phenyl-4-diethylcarbamoylpiperazine at room temperature, and the solution was saturated with gaseous hydrogen chloride and stirred for a certain time. The solvent was removed by distillation under reduced pressure. Then, 50 ml of acetone was added to the residue and the mixture was stirred for a certain time. The precipitated crystal was recovered by filtration, washed with acetone, stirred in 50 ml of acetone to effect washing and dried to obtain 2.1 g of 1-phenyl-4-diethylcarbamoylpiperazine hydrochloride having a melting point of 190° to 192° C. The yield was 70.9%. The elementary analysis values are as follows.

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