Ethanol → HCID 13042077, compound

Participants

Reaction Steps

To 3.3 g (0.01 mole) of 1-(4-ethoxycarbonylphenyl)-4-diethylcarbamoylpiperazine obtained in Example 6 were added 90 ml of ethanol, 10 ml of water and 1.0 g of sodium hydroxide, and the mixture was heated and refluxed under stirring for 3.5 hours. The solvent was removed by distillation under reduced pressure, and 100 ml of water was added to the residue and the insoluble substance was removed. The pH value of the filtrate was adjusted to 3 by 2 N hydrochloric acid. The precipitate was recovered by filtration and dissolved in a dilute aqueous solution of sodium hydroxide, and the pH value was adjusted to 3 again by 2 N hydrochloric acid. The precipitate was recrystallized from methanol to obtain 1.5 g of 1-(4-carboxyphenyl)-4-diethylcarbamoylpiperazine having a melting point of 207° to 209.5° C. The elementary analysis values are as follows.

Provenance & Evidence