Sodium Hydroxide → HCID 12805850, compound

Participants

Reaction Steps

A solution of 7.0 g (0.03 mole) 1-amidino-3-(2,6-dimethylphenyl)-thiourea in 150 ml methylene chloride is stirred with 4.2 g (0.03 mole) N-chlorosuccinimide (95%) for 1 hour at 20° C., then for another hour after the addition of 15 ml conc. NaOH. After dilution with water, the methylene chloride phase is separated by filtration and, by column-chromatography with silica gel (MeOH/CHCl3 : 10/90), 4.8 g 3-amino-5-(2,6-dimethylphenylamino)-1,2,4-thiadiazole having a melting point of 180° C. is obtained.

Provenance & Evidence