Acetic Anhydride → HCID 12805840, compound

HRID 543483Notes

Reaction equation

HRID 543483 reaction equation
[NH2:1][C:2]1[N:6]=[C:5]([NH:7][C:8]2[C:13]([Cl:14])=[CH:12][CH:11]=[CH:10][C:9]=2[Cl:15])[O:4][N:3]=1.[CH3:16][C:17](OC(C)=O)=[O:18]>N1C=CC=CC=1>[NH2:1][C:2]1[N:6]=[C:5]([N:7]([C:17](=[O:18])[CH3:16])[C:8]2[C:13]([Cl:14])=[CH:12][CH:11]=[CH:10][C:9]=2[Cl:15])[O:4][N:3]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 12805833HCID 12805833, compound

Product 1

HCID 12805840HCID 12805840, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2.4 g (0.01 mole) 3-amino-5-(2,6-dichlorophenylamino)-1,2,4-oxadiazole in 10 ml pyridine are mixed with 5 moles acetanhydride at room temperature and stirred for 2 hours at 25°-30° C. After evaporation of the solvent, the residue is taken up at CHCl3 and shaken with sodium hydrogen carbonate solution. The CHCl3 phase contains 3 g of the N-acetyl compound, which is purified by column-chromatography on silica gel. The product has a melting point of 164°-165° C.

Workup

  1. customAfter evaporation of the solvent
  2. stirringshaken with sodium hydrogen carbonate solution
  3. customis purified by column-chromatography on silica gel

Sources & evidence

ORD record
ord-f7ab9bef09754f9f8c9ef1ad5486fcdb
Source dataset
uspto-grants-1984_05
Patent number
US04446142

Reaction notes

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