Sodium borohydride → HCID 12915865, compound

HRID 543493Notes

Reaction equation

HRID 543493 reaction equation
[O:1]=[C:2]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH2:3][N:4]1[CH2:9][CH2:8][CH:7]([N:10]2[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=3[NH:12][C:11]2=[O:19])[CH2:6][CH2:5]1.[BH4-].[Na+]>CO>[OH:1][CH:2]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH2:3][N:4]1[CH2:5][CH2:6][CH:7]([N:10]2[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=3[NH:12][C:11]2=[O:19])[CH2:8][CH2:9]1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 12915849HCID 12915849, compound

Product 1

HCID 12915865HCID 12915865, compoundYield 67.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1.91 g of the product obtained in Example 24 is dissolved in 30 ml of methanol, and reacted with 1.1 g of sodium borohydride under the same conditions as in Example 7 to obtain 1.62 g of a crude product. Recrystallization of the product from ethanol yields 1.3 g of 1-[2-hydroxy-2-phenyl-1-ethyl]-4-(2-keto-1-benzimidazolinyl)-piperidine.

Workup

  1. customto obtain 1.62 g of a crude product
  2. customRecrystallization of the product from ethanol

Sources & evidence

ORD record
ord-813f40faef2d4a0ea698f8be6f31e977
Source dataset
uspto-grants-1984_05
Patent number
US04446141

Reaction notes

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