Dimethylformamide → HCID 12811315, compound

Participants

Reaction Steps

A solution of 2.0 g of 1-[3-hydroxy-3-(3,4-dimethoxyphenyl)-2-propyl]-4-(2-keto-1-benzimidazolinyl)-piperidine and 0.6 g of 4-dimethylaminopyridine in 10 ml of dimethylformamide is stirred at room temperature for 12 hours. Dimethylformamide is distilled away under reduced pressure to obtain a residue. The residue is dissolved in 20 ml of ethyl acetate. To the solution is added 0.6 g of triethylamine. The mixture is washed five times with 20 ml of water and dried. Recrystallization of the crystals from a mixture of dioxane and ether (1:1) yields 1.21 g of 1-[3-hydroxy-3-(3,4-dimethoxyphenyl)-2-propyl]-4-(3-acetyl-2-keto-1-benzimidazolinyl)-piperidine.

Provenance & Evidence