Hydrochloric Acid → HCID 13239721, compound

Participants

Reaction Steps

8.2 g of methyl 2,2-ethylenedioxypropyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate was refluxed in 35 ml of an ethanol solution containing 5 ml of 10% hydrochloric acid for 6 hours. The solvent was then distilled off and the residue was crystallized from diethyl ether. Recrystallization of the crystals from a mixture of ethyl acetate and hexane gave 4.8 g (65% yield) of methyl 2-oxopropyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate as yellow prisms having a melting point of 139° C.

Provenance & Evidence