HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-(3-bromo-4-difluoromethoxyphenyl)-1-methylcyclopropanecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 1-Methylcyclopropane-1-carbonyl chloride | HCID 12789939 | — |
| Reactant | 3-Bromo-4-(difluoromethoxy)aniline | HCID 13295032 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | N-(3-bromo-4-difluoromethoxyphenyl)-1-methylcyclopropanecarboxamide | HCID 13314708 | 96% |
Reaction Steps
In the same manner as in Example 3 but using 3-bromo-4-difluoromethoxyaniline (2.4 g) and 1-methylcyclopropanecarbonyl chloride (1.2 g) with pyridine (0.8 g) as the hydrogen chloride-eliminating agent and ethyl acetate as the solvent, the operations were effected to give N-(3-bromo-4-difluoromethoxyphenyl)-1-methylcyclopropanecarboxamide (3.1 g). M.P., 71°-71.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04447260 |
| Source dataset | uspto-grants-1984_05 |
| ORD ID | ord-29662b1cb7b847b7b138451e86bf353a |
| Source note | uspto-grants-1984_05 |