2-Chloro-3-pyridylamine → [2-[(3-Amino-2-pyridinyl)amino]phenyl](3-thienyl)methanone

HRID 543608Notes

Reaction equation

HRID 543608 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([C:10]1[CH:14]=[CH:13][S:12][CH:11]=1)=[O:9].[NH2:15][C:16]1[C:17](Cl)=[N:18][CH:19]=[CH:20][CH:21]=1>>[NH2:15][C:16]1[C:17]([NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=2[C:8]([C:10]2[CH:14]=[CH:13][S:12][CH:11]=2)=[O:9])=[N:18][CH:19]=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 805282-Chloro-3-pyridylamineHCID 127505413-(Amino-benzoyl)thiophene

Product 1

HCID 20200359[2-[(3-Amino-2-pyridinyl)amino]phenyl](3-thienyl)methanone

Procedure

In accordance with the procedure of Intermediate 9, (2-aminophenyl)(3-thienyl)methanone is reacted with 3-amino-2-chloropyridine to give the title compound.

Sources & evidence

ORD record
ord-a1b80b163a64447cb2d8554edf3a516b
Source dataset
uspto-grants-1984_05
Patent number
US04447361

Reaction notes

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