Ethyl orthoformate → HCID 15586699, compound

HRID 543626Notes

Reaction equation

HRID 543626 reaction equation
[C:1]1([C:7]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[N:11]([CH2:18][CH2:19][CH2:20][NH2:21])[C:10]3[N:22]=[CH:23][CH:24]=[CH:25][C:9]=3[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:26]([O:28][CH:29](OCC)OCC)[CH3:27]>>[CH2:26]([O:28][CH:29]=[N:21][CH2:20][CH2:19][CH2:18][N:11]1[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[N:8][C:9]2[CH:25]=[CH:24][CH:23]=[N:22][C:10]1=2)[CH3:27]

Participants

3

Reactant 2

HCID 31214Ethyl orthoformateHCID 15586690HCID 15586690, compound

Product 1

HCID 15586699HCID 15586699, compound

Procedure

A solution of 8.8 g (0.021 mole) of 6-phenyl-11H-pyrido [2,3-b][1,4]bezodiazepine-11-propanamine in 150 ml of triethylorthoformate was heated at refux for 41/2 hr and allowed to stand overnight. The mixture was concentrated in vacuo, the residue was washed with pet-ether (30°-60° C.). Chemical ionization mass spec indicated the product was a mixture containing the title compound.

Workup

  1. concentrationThe mixture was concentrated in vacuo
  2. washthe residue was washed with pet-ether (30°-60° C.)
  3. additioncontaining the title compound

Sources & evidence

ORD record
ord-032c2a905138499f964e41cab99dd0e4
Source dataset
uspto-grants-1984_05
Patent number
US04447361

Reaction notes

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