Acetic Anhydride → HCID 22826492, compound

Participants

Reaction Steps

Acetic anhydride (1.21 ml) was added to a solution of 2β,16β-di-(1-piperidinyl)-5α-androstan-17β-ol (3.77 g) in dry pyridine (75 ml) at 0°-5° C. and the solution was set aside at room temperature for 19 h. Saturated sodium carbonate solution (40 ml) was added to precipitate the product, which was filtered off and washed well with water (200 ml). A solution of the crude product in diethyl ether (50 ml) was washed with water (2×100 ml), dried (MgSO4) and concentrated to afford 2β,16β-di-(1-piperidinyl)-5α-androstan-17β-ol acetate (3.91 g), m.p. 156°-161° C.; [α]D +28.7° (c 0.47 in CHCl3).

Provenance & Evidence