Sodium Hydroxide → HCID 178524765, compound

HRID 543659Notes

Reaction equation

HRID 543659 reaction equation
[CH2:1]([NH:7][C:8]1[N:13]=[C:12]([OH:14])[C:11]([C:15]([O:17]CC)=[O:16])=[CH:10][N:9]=1)[C:2]1[O:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>O>[CH2:1]([NH:7][C:8]1[N:13]=[C:12]([OH:14])[C:11]([C:15]([OH:17])=[O:16])=[CH:10][N:9]=1)[C:2]1[O:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178469827HCID 178469827, compound

Product 1

HCID 178524765HCID 178524765, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-Furfurylamino-5-ethoxycarbonyl-4-hydroxypyrimidine (526 mg, 2 mmol) was hydrolysed in water (10 ml) with NaOH (5 mmol, 200 mg) by refluxing for 3 h. Cooling and acidification to pH 2 yielded the named product as a precipitate. (435 mg, 93% yield).

Workup

  1. temperatureby refluxing for 3 h
  2. temperatureCooling
  3. customacidification to pH 2 yielded the named product as a precipitate

Sources & evidence

ORD record
ord-3ff1f23703f8428eaa9c0fadcbfee765
Source dataset
uspto-grants-1984_05
Patent number
US04447422

Reaction notes

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