Sodium Hydroxide → HCID 178456850, compound

HRID 543664Notes

Reaction equation

HRID 543664 reaction equation
[CH2:1]([NH:4][C:5]1[N:10]=[C:9]([OH:11])[C:8]([C:12]([O:14]CC)=[O:13])=[CH:7][N:6]=1)[CH:2]=[CH2:3].[OH-].[Na+]>O>[CH2:1]([NH:4][C:5]1[N:10]=[C:9]([OH:11])[C:8]([C:12]([OH:14])=[O:13])=[CH:7][N:6]=1)[CH:2]=[CH2:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178456848HCID 178456848, compound

Product 1

HCID 178456850HCID 178456850, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-Allylamino-5-ethoxycarbonyl-4-hydroxypyrimidine (585 mg, 2.5 mmol) was hydrolysed in boiling water with NaOH (300 mg, 7.5 mmol) for 2 hours. Cooling and acidification to pH 2 yielded the title acid (321 mg, 66%).

Workup

  1. customfor 2 hours
  2. temperatureCooling
  3. customacidification to pH 2 yielded the title acid (321 mg, 66%)

Sources & evidence

ORD record
ord-c75ab073d76a48c1a6d6d1dcc36dcb54
Source dataset
uspto-grants-1984_05
Patent number
US04447422

Reaction notes

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