Chlorotrimethylsilane → HCID 178522540, compound

Participants

Reaction Steps

2-Amino-4-hydroxypyrimidine-5-carboxylic acid (310 mg, 2 mmol) was suspended in chloroform (20 ml) and treated with triethylamine (880 μl, 6.2 mmol) and trimethylsilylchloride (850 μl, 6.2 mmol) at reflux for 4 hours. Benzoyl chloride (250 μl, 2 mmol) was added and the reaction mixture allowed to cool overnight. Water (10 ml) was added with very vigorous stirring and the solid product was dissolved in the aqueous layer by addition of 10% NaOH. After washing the aqueous layer with further chloroform, the product was precipitated by acidification to pH 0. The filtered product was washed with water and ether. Yield 374 mg (72%)

Provenance & Evidence