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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 543692Generated: October 31, 2026

Formaldehyde → 6-Chloro-3-(hydroxymethyl)-4-quinolinol

https://huagongshe.com/reaction/543692

Reaction equation

Participants

RoleNameHCIDCharge
ReactantFormaldehydeHCID 712—
ReactantHCID 178516411HCID 178516411—
SolventSodium HydroxideHCID 14798—
Product6-Chloro-3-(hydroxymethyl)-4-quinolinolHCID 178519807—

Reaction Steps

6-Chloro-4-hydroxyquinoline was reacted with formaldehyde in aqueous sodium hydroxide at 55° for 24 hours to give the novel compound 6-chloro-4-hydroxy-3-hydroxymethylquinoline, m.p.>300°.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04447435
Source datasetuspto-grants-1984_05
ORD IDord-b80cf1a28896488c84dd8342a6cc5dd7
Source noteuspto-grants-1984_05