Dimethylamine → HCID 13179835, compound

Participants

Reaction Steps

2.5 ml of acetic acid and then 1.4 ml of an aqueous 40% formaldehyde solution were slowly added with stirring at 0° to 5° C. under an inert atmosphere to 2.5 ml of an aqueous 35% dimethylamine solution and then a solution of 5.5 g of 4-(1-benzyl-piperidin-3-yl)-1H-indole in 25 ml of acetic acid was added to the mixture. The mixture was stirred at room temperature for 90 minutes and was then diluted with water. Sodium hydroxide was added to the mixture to make it basic and the mixture was filtered. The recovered product was washed with water, dried under reduced pressure and crystallized from benzene to obtain 3 g of N,N-dimethyl-4-(1-benzyl-piperidin-3-yl)-1H-indole-3-methanamine melting at ≃150° C.

Provenance & Evidence