HCID 13179835, compound → HCID 13179836, compound

Participants

Reaction Steps

A stirred mixture of 4.3 g of the product of Step A, 1.5 g of 10% palladized carbon and 300 ml of methanol was hydrogenated at 40° C. for one hour after which another 1.5 g of 10% palladized carbon were added. The hydrogenation was continued for another hour and the mixture was filtered. The filtrate was evaporated to dryness under reduced pressure at 50° C. to obtain 2.5 g of 3-methyl-4-(piperidin-3-yl)-1H-indole melting at 150° C. The said product was dissolved in 250 ml of ethyl acetate and then a solution of hydrogen chloride in ethyl acetate was added thereto at 0° to 5° C. until the mixture was acidic. The mixture was filtered and the product was washed with ethyl acetate, dried at 50° C. under reduced pressure and was crystallized from isopropanol to obtain 2.4 g of 3-methyl-4-(piperidin-3-yl)-1H-indole hydrochloride melting at 280° C.

Provenance & Evidence