Bromine → HCID 13247732, compound

Participants

Reaction Conditions

Reaction Steps

A solution of bromine (1.12 g) in glacial acetic acid (2 ml) was added dropwise at 60° C. with stirring to a solution of 1-methyl-4-piperidyl 1,2-benzisoxazole-3-acetate hydrobromide (2.0 g) in glacial acetic acid (8 ml). The reaction mixture was stirred for 3 hours at 60° C. and then concentrated in vacuo to about a half volume. The residue was dissolved in acetone and thereto was added diethyl ether until it became turbid. After cooling, the resulting crystals were collected by filtration to give 1-methyl-4-piperidyl 2-bromo-2-(1,2-benzisoxazol-3-yl)acetate hydrobromide (1.9 g). An analytical sample was obtained by recrystallization from ethanol, m.p. 169°-171° C.

Provenance & Evidence