Methanol → HCID 70509492, compound

Participants

Reaction Steps

2.3 g (0.005 mol) of 5,10-dihydro-5-[(4-pyridinyl)carbonyl]-11H-dibenzo[b,e][1,4]diazepin-11-one methoiodide were suspended in 200 ml of methanol and at 0° C. 0.25 g (0.006 mol) of sodium borohydride were added in batches. The mixture was stirred for a further hour in the ice bath. It was then stirred into 1 liter of ice-cold water and extracted exhaustively with methylene chloride. The combined extracts were washed with water, dried over sodium sulphate and concentrated by evaporation in vacuo. After recrystallization from diisopropylether/methanol, the colorless crystals melted at 233°-234° C.

Provenance & Evidence