Triethyl phosphite → HCID 20460466, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 143 g (0.43 mol) of 5-bromoacetyl-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one and 400 ml of triethylphosphite was refluxed for 2 hours at 120° C., with stirring. In the course of the reaction, the 5-bromoacetyl compound went fully into solution and a grey precipitate began to settle out. After cooling, this was suction filtered and washed with ethyl acetate and 159 g (95% of theory) of 5-diethylphosphonoacetyl-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one were obtained; m.p. 195°-197° C.

Provenance & Evidence