HCID 13285855, compound → HCID 13285858, compound

Participants

Reaction Steps

3.5 g (0.01 mol) of 5,10-dihydro-5-[(1-methyl-1,2,5,6-tetrahydro-4-pyridinyl)acetyl]-11H-dibenzo[b,e][1,4]diazepin-11-one were dissolved in 100 ml of ethanol and hydrogenated in the presence of 0.5 g of platinum oxide at ambient temperature and under a pressure of 3 bar. After the uptake of hydrogen had ended, the catalyst was filtered out and the remaining mixture concentrated by evaporation in vacuo. The residue was purified by column chromatography (NM silica gel 60; 0.063-0.2 mm particle size; eluent; ethyl acetate/methanol=9:1) and 3.2 g (91% of theory) of 5,10-dihydro-5-[(1-methyl-4-piperidinyl)acetyl]-11H-dibenzo[b,e][1,4]diazepin-11-one was obtained, which was identical, according to thin layer chromatography, elementary analysis and IR spectrum, to the product obtained using the method of Example 4.

Provenance & Evidence