HCID 13883776, compound → HCID 13883778, compound

HRID 543758Notes

Reaction equation

HRID 543758 reaction equation
[NH2:1][C:2]1[CH:6]=[CH:5][N:4]([CH2:7][CH2:8][CH2:9][CH2:10][C:11]#[N:12])[N:3]=1.[F:13][C:14]([F:20])([F:19])[CH2:15][N:16]=[C:17]=[S:18]>C(#N)C>[F:13][C:14]([F:20])([F:19])[CH2:15][NH:16][C:17](=[S:18])[NH:1][C:2]1[CH:6]=[CH:5][N:4]([CH2:7][CH2:8][CH2:9][CH2:10][C:11]#[N:12])[N:3]=1

Participants

4

Reactant 2

HCID 13883776HCID 13883776, compoundHCID 138837771,1,1-Trifluoro-2-isothiocyanatoethane

Product 1

HCID 13883778HCID 13883778, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of 5-(3-aminopyrazol-1-yl)valeronitrile (7.0 g.) in acetonitrile (25 ml.) was added 2,2,2-trifluoroethylisothiocyanate (6.02 g.). After 15 minutes the solvent was evaporated in vacuo to give 5-(3-[3-(2,2,2-trifluoroethyl)thioureido]pyrazol-1-yl)valeronitrile as a white crystalline solid, m.p. 96°-98°.

Workup

  1. customAfter 15 minutes the solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-456aeda7c1c24f6aa9bf3ceebb33dd54
Source dataset
uspto-grants-1984_05
Patent number
US04447441

Reaction notes

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