Ammonia → HCID 13883780, compound

HRID 543759Notes

Reaction equation

HRID 543759 reaction equation
[F:1][C:2]([F:20])([F:19])[CH2:3][NH:4][C:5](=S)[NH:6][C:7]1[CH:11]=[CH:10][N:9]([CH2:12][CH2:13][CH2:14][CH2:15][C:16]#[N:17])[N:8]=1.[NH3:21]>CCO>[F:1][C:2]([F:20])([F:19])[CH2:3][N:4]=[C:5]([NH2:21])[NH:6][C:7]1[CH:11]=[CH:10][N:9]([CH2:12][CH2:13][CH2:14][CH2:15][C:16]#[N:17])[N:8]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 13883778HCID 13883778, compound

Product 1

HCID 13883780HCID 13883780, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The above thiourea (12.5 g.) was dissolved in 8 M ammonia in EtOH (120 ml.). Mercuric oxide (12.8 g.) was added and the mixture was stirred at 20° for 30 minutes. The resulting mixture was filtered and the filtrate was evaporated in vacuo to give 5-[3-(2-[2,2,2-trifluoroethyl]guanidino)pyrazol-1-yl]valeronitrile as an oil. A sample of the oil was dissolved in acetone and 5 molecular equivalents of maleic acid was added. Ether was added to the resulting clear solution to produce the crystalline maleate, m.p. 123°-125°.

Workup

  1. filtrationThe resulting mixture was filtered
  2. customthe filtrate was evaporated in vacuo

Sources & evidence

ORD record
ord-21ea65d9929045f2945947b16721dd07
Source dataset
uspto-grants-1984_05
Patent number
US04447441

Reaction notes

Loading…