Sodium Hydroxide → HCID 13883775, compound

HRID 543761Notes

Reaction equation

HRID 543761 reaction equation
[N+:1]([C:4]1[CH:8]=[CH:7][N:6]([CH2:9][CH2:10][CH2:11][CH2:12][C:13]#[N:14])[N:5]=1)([O-:3])=[O:2].[OH-:15].[Na+]>S(=O)(=O)(O)O.O>[N+:1]([C:4]1[CH:8]=[CH:7][N:6]([CH2:9][CH2:10][CH2:11][CH2:12][C:13]([NH2:14])=[O:15])[N:5]=1)([O-:3])=[O:2]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 12052140HCID 12052140, compound

Product 1

HCID 13883775HCID 13883775, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 1118Sulfuric AcidSolvent

Procedure

A solution of 5-(3-nitropyrazol-1-yl)valeronitrile (0.2 g.) in concentrated sulphuric acid (1 ml.) was kept at 20° for 19 hours. The mixture was diluted with water (4 ml.), basified to pH 10 with 10.8 N sodium hydroxide and extracted with EtOAc (3×5 ml.). The extracts were dried (MgSO4) and evaporated in vacuo to a white solid which was recrystallised from ethanol to give 5-(3-nitropyrazol-1-yl)valeramide, m.p. 129°-131°.

Workup

  1. extractionextracted with EtOAc (3×5 ml.)
  2. dry with materialThe extracts were dried (MgSO4)
  3. customevaporated in vacuo to a white solid which
  4. customwas recrystallised from ethanol

Sources & evidence

ORD record
ord-c1d31128146c4f65bc718bba5386402b
Source dataset
uspto-grants-1984_05
Patent number
US04447441

Reaction notes

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