Ammonia → HCID 70444113, compound

Participants

Reaction Steps

A mixture of 3-[4-(3-[2,2,2-trifluoroethyl]thioureido)-1,2,3-triazol-2-yl]cyclopentanecarboxamide (0.34 g.), mercuric oxide (0.4 g.) and methanolic ammonia (6 M; 20 ml.) was stirred at room temperature for 3 hours. The mixture was kept at room temperature overnight, filtered, and evaporated to give 0.27 g. of 3-[4-(2-[2,2,2-trifluoroethyl]guanidino)-1,2,3-triazol-2-yl]cyclopentanecarboxamide. A sample in a small volume of EtOAc was treated with an equivalent of maleic acid in a small volume of acetone to give, on addition of ether, 3-[4-(2-[2,2,2-trifluoroethyl]guanidino)-1,2,3-triazol-2-yl]cyclopentanecarboxamide maleate, m.p. 143°-146°.

Provenance & Evidence