反应详情

To a solution of 2-amino-6-chloropyrazine (6 g.) in acetonitrile (50 ml.) was added 2,2,2-trifluoroethylisothiocyanate (6 ml.) and the mixture heated under reflux on a steam bath for 6 hours. The mixture was allowed to cool, the resulting solid filtered and recrystallised from toluene to give 2-chloro-6-(3-[2,2,2-trifluoroethyl]thioureido)pyrazine.

1. temperaturethe mixture heated
2. temperatureunder reflux on a steam bath for 6 hours
3. temperatureto cool
4. filtrationthe resulting solid filtered
5. customrecrystallised from toluene