Ammonia → HCID 21279856, compound

HRID 543784Notes

Reaction equation

HRID 543784 reaction equation
[F:1][C:2]([F:20])([F:19])[CH2:3][NH:4][C:5](=S)[NH:6][C:7]1[N:11]=[CH:10][N:9]([CH2:12][CH2:13][CH2:14][CH2:15][C:16]#[N:17])[N:8]=1.[NH3:21]>CO.C(#N)C>[F:1][C:2]([F:20])([F:19])[CH2:3][N:4]=[C:5]([NH2:21])[NH:6][C:7]1[N:11]=[CH:10][N:9]([CH2:12][CH2:13][CH2:14][CH2:15][C:16]#[N:17])[N:8]=1

Participants

5

Reactant 2

HCID 222AmmoniaHCID 54220720HCID 54220720, compound

Product 1

HCID 21279856HCID 21279856, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6342AcetonitrileSolvent

Procedure

This nitrile (3.6 g.) in MeOH (80 ml.) and acetonitrile (5 ml.) was treated with mercuric oxide (3.06 g.) and methanolic ammonia (15 ml.). After stirring for 1.5 hours the black suspension was filtered through diatomaceous earth and the filtrates evaporated to give a white solid. The solid was washed with ether and filtered to give 5-[3-(2-[2,2,2-trifluoroethyl]guanidino)-1,2,4-triazol-1-yl]valeronitrile (2.87 g.) as a white solid, m.p. 200°-201° after recrystallisation from EtOH.

Workup

  1. filtrationwas filtered through diatomaceous earth
  2. customthe filtrates evaporated
  3. customto give a white solid
  4. washThe solid was washed with ether
  5. filtrationfiltered

Sources & evidence

ORD record
ord-2839f42477f74e03842702e9f9c57d11
Source dataset
uspto-grants-1984_05
Patent number
US04447441

Reaction notes

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