HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(3-Amino-1H-pyrazol-1-yl)pentanamide → 3-((Imino((2,2,2-trifluoroethyl)amino)methyl)amino)1H-pyrazole-1-pentamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(3-Amino-1H-pyrazol-1-yl)pentanamide | HCID 20202775 | — |
| Reactant | Chloroform methanol ammonia | HCID 21866414 | — |
| Reactant | HCID 178504040 | HCID 178504040 | — |
| Product | 3-((Imino((2,2,2-trifluoroethyl)amino)methyl)amino)1H-pyrazole-1-pentamide | HCID 134778 | — |
Reaction Steps
A mixture of 5-(3-aminopyrazol-1-yl]valeramide (18.2 mg.) and (2,2,2-trifluoroethyl)-S-methylisothiourea hydroiodide (51 mg.) was heated at 100° for 20 minutes. Preparative high pressure liquid chromatography on silica gel, using CHCl3 /MeOH/ammonia (s.g. 0.880) 8:2:0.5 v/v/v as eluant gave 5-[3-(2-[2,2,2-trifluoroethyl]guanidino)pyrazol-1-yl]valeramide, m.p. 129°-130° (40%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04447441 |
| Source dataset | uspto-grants-1984_05 |
| ORD ID | ord-009ef290223244d8848b37b9cb02da69 |
| Source note | uspto-grants-1984_05 |