Methyl iodide → HCID 178504040, compound

HRID 543794Notes

Reaction equation

HRID 543794 reaction equation
[F:1][C:2]([F:9])([F:8])[CH2:3][NH:4][C:5]([NH2:7])=[S:6].[CH3:10][I:11]>CCO>[IH:11].[F:1][C:2]([F:9])([F:8])[CH2:3][NH:4][C:5](=[NH:7])[S:6][CH3:10]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 202028121-(2,2,2-Trifluoroethyl)thiourea

Product 1

HCID 178504040HCID 178504040, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2,2,2-trifluoroethylthiourea (8.0 g.) and methyl iodide (3.5 g.) in EtOH (40 ml.) was heated under reflux for 70 minutes, then evaporated to dryness in vacuo. The residue was triturated with ether to give 2,2,2-trifluoroethyl-S-methylisothiourea hydroiodide, m.p. 154°-156° (90%).

Workup

  1. temperatureunder reflux for 70 minutes
  2. customevaporated to dryness in vacuo
  3. customThe residue was triturated with ether

Sources & evidence

ORD record
ord-eb664b0dcd9f44d985ecb0985c5b3da2
Source dataset
uspto-grants-1984_05
Patent number
US04447441

Reaction notes

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