Acetic Anhydride → Acetamide, N-(4,5-dihydro-1-phenyl-1H-pyrazol-3-yl)-

HRID 543805Notes

Reaction equation

HRID 543805 reaction equation
F[C:2](F)(F)[C:3]([NH:5][C:6]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][C:14](C(=O)C(F)(F)F)=[CH:13][CH:12]=2)[N:7]=1)=[O:4].C(OC(=O)C)(=O)C>>[C:11]1([N:8]2[CH2:9][CH2:10][C:6]([NH:5][C:3](=[O:4])[CH3:2])=[N:7]2)[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 15580703HCID 15580703, compound

Product 1

HCID 793093Acetamide, N-(4,5-dihydro-1-phenyl-1H-pyrazol-3-yl)-

Procedure

A 10.0 g. amount of 3-amino-1-phenyl-2-pyrazoline (prepared in Example 8) and 10.0 ml. of acetic anhydride are mixed together and allowed to stand at room temperature for one hour. The resulting solid is collected, dissolved in dichloromethane and passed through a short column of a hydrous magnesium silicate. The effluent is heated and hexane is added to crystallize 1.2 g. of the desired product as yellow prisms, m.p. 190°-191° C.

Workup

  1. customThe resulting solid is collected
  2. dissolutiondissolved in dichloromethane
  3. temperatureThe effluent is heated
  4. additionhexane is added
  5. customto crystallize 1.2 g

Sources & evidence

ORD record
ord-fec04c99ecac418591f684f81c1828a2
Source dataset
uspto-grants-1984_05
Patent number
US04447442

Reaction notes

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