Formic Acid → HCID 15580711, compound

HRID 543806Notes

Reaction equation

HRID 543806 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:12][CH2:11][C:10]([NH:13][C:14](=[O:19])C(F)(F)F)=[N:9]2)[CH:5]=[CH:6][CH:7]=1.C(O)=O.ClC1C=C(N2CC(C)C(NC=O)=N2)C=CC=1Cl>ClCCl>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:12][CH2:11][C:10]([NH:13][CH:14]=[O:19])=[N:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 284Formic AcidHCID 15580693HCID 15580693, compoundHCID 15580721HCID 15580721, compound

Product 1

HCID 15580711HCID 15580711, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 2.0 g. of 3-amino-1-(m-chlorophenyl)-2-pyrazoline (prepared in Example 10) and 10 ml. of a mixture of formic acid and acetic anhydride (Example 15) is allowed to stand at room temperature for 30 minutes. Then the solvent is evaporated in vacuo to give an oil. The oil is dissolved in dichloromethane and is columnized and recrystallized as described in Example 5 to give 1.32 g. of the desired product as pale yellow needles, m.p. 143°-145° C.

Workup

  1. additionA mixture of 2.0 g
  2. customThen the solvent is evaporated in vacuo
  3. customto give an oil
  4. customrecrystallized
  5. customto give 1.32 g

Sources & evidence

ORD record
ord-5dd5727a5f334c8191869b11aeee9fef
Source dataset
uspto-grants-1984_05
Patent number
US04447442

Reaction notes

Loading…