Formic Acid → HCID 15580709, compound

HRID 543817Notes

Reaction equation

HRID 543817 reaction equation
FC(F)(F)[C:3]([NH:5][C:6]1[CH2:10][CH:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:8]([C:17]2[CH:22]=[CH:21][C:20](C(=O)C(F)(F)F)=[CH:19][CH:18]=2)[N:7]=1)=[O:4].C(O)=O.ClC1C=C(N2CC(C)C(NC=O)=N2)C=CC=1Cl.CCCCCC>ClCCl>[C:17]1([N:8]2[CH:9]([C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH2:10][C:6]([NH:5][CH:3]=[O:4])=[N:7]2)[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

6

Reactant 4

HCID 284Formic AcidHCID 8058HexaneHCID 15580705HCID 15580705, compoundHCID 15580721HCID 15580721, compound

Product 1

HCID 15580709HCID 15580709, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 5.0 g. of 3-amino-1,5-diphenyl-2-pyrazoline (prepared as described in Example 4) and 25.0 ml. of a mixture of formic acid and acetic anhydride (Example 15) is allowed to remain at room temperature for 30 minutes. The hexane is added and the mixture is filtered. The solid obtained is dissolved in dichloromethane. The solution is columnized and recrystallized as described in Example 14 (B) to yield 3.55 g. of the product of the Example as off-white needles, m.p. 158°-160° C.

Workup

  1. additionA mixture of 5.0 g
  2. filtrationthe mixture is filtered
  3. customThe solid obtained
  4. customrecrystallized
  5. customto yield 3.55 g

Sources & evidence

ORD record
ord-6810c6fb949740f8a66330ee73342a8d
Source dataset
uspto-grants-1984_05
Patent number
US04447442

Reaction notes

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