Formic Acid → HCID 15580716, compound

HRID 543824Notes

Reaction equation

HRID 543824 reaction equation
[NH2:1][C:2]1[CH2:6][CH:5]([C:7]2[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=2)[N:4]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[N:3]=1.[CH:21](O)=[O:22].ClC1C=C(N2CC(C)C(NC=O)=N2)C=CC=1Cl>O>[Cl:20][C:17]1[CH:18]=[CH:19][C:14]([N:4]2[CH:5]([C:7]3[CH:8]=[CH:9][C:10]([Cl:13])=[CH:11][CH:12]=3)[CH2:6][C:2]([NH:1][CH:21]=[O:22])=[N:3]2)=[CH:15][CH:16]=1

Participants

5

Reactant 3

HCID 284Formic AcidHCID 15580674HCID 15580674, compoundHCID 15580721HCID 15580721, compound

Product 1

HCID 15580716HCID 15580716, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 1.85 g. of 3-amino-1,5-bis(p-chlorophenyl)-2-pyrazoline (prepared as described above) and 10.0 ml. of a mixture of formic acid and acetic anhydride (Example 15) is allowed to remain at room temperature for 2 hours, then water is added and the mixture is filtered to collect a semi-solid. The solid is dissolved in dichloromethane and the solution is columnized and recrystallized twice as for Example 26 (A) to yield 1.10 g. of the product of the Example as off-white crystals, m.p. 198°-200° C.

Workup

  1. additionA mixture of 1.85 g
  2. filtrationthe mixture is filtered
  3. customto collect a semi-solid
  4. dissolutionThe solid is dissolved in dichloromethane
  5. customto yield 1.10 g

Sources & evidence

ORD record
ord-07e7cc44445449409605e89c9e72a438
Source dataset
uspto-grants-1984_05
Patent number
US04447442

Reaction notes

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