Nitric Acid → HCID 10542584, compound

HRID 54384Notes

Reaction equation

HRID 54384 reaction equation
[Cl:1][C:2]1[C:3]([F:16])=[C:4]([NH:9][C:10](=[O:15])[C:11]([F:14])([F:13])[F:12])[CH:5]=[CH:6][C:7]=1[F:8].[N+:17]([O-])([OH:19])=[O:18]>OS(O)(=O)=O>[Cl:1][C:2]1[C:3]([F:16])=[C:4]([NH:9][C:10](=[O:15])[C:11]([F:12])([F:13])[F:14])[C:5]([N+:17]([O-:19])=[O:18])=[CH:6][C:7]=1[F:8]

Participants

4

Reactant 2

HCID 944Nitric Acid2×HCID 104915413-Chloro-2,4-difluoro-(trifluoroacetamido)benzene

Product 1

HCID 10542584HCID 10542584, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

To a solution of 15.1 g (58.1 mmol) of 3-chloro-2,4-difluoro-(trifluoroacetamido)benzene in 80 mL of H2SO4 kept in an ice-bath was added dropwise 10 mL of HNO3. Solid precipitate was observed during addition of HNO3. The mixture was stirred in an ice-bath for 4 h. It was added into 600 mL of ice-water. The precipitate was filtered and washed by water, and dried to leave almost colorless solid (16.8 g, 95%), mp 124°-125° C. 1H NMR (CDCl3), 7.69 (dd, 1), 8.936 (mb, 1).

Workup

  1. filtrationThe precipitate was filtered
  2. washwashed by water
  3. customdried

Sources & evidence

ORD record
ord-22b48c173e994322995649a15ad25a9e
Source dataset
uspto-grants-1997_04
Patent number
US05622952

Reaction notes

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