3-Bromo-4-(4-chlorophenyl)-4-oxobutanoic acid → HCID 20461139, compound

Participants

Reaction Steps

A solution of 3-bromo-3-(p-chlorobenzoyl) propionic acid (7.29 g, 0.025 moles) in methanol (40 ml) was mixed with a solution of 5-methyl-3,4,5,6-tetrahydro-s-triazin-2(1H)-thione (3.27 g, 0.025 moles) in the same solvent (150 ml) and left for one hour. Evaporation of the solvent gave 7-carboxymethyl-6-(p-chlorophenyl)-6-hydroxy-3-methyl-3,4,6,7-tetrahydro-2H-thiazolo[3,2-a]-s-triazine hydrobromide as a pale yellow solid (9.6 g), m.p. 111°-113° C.

Provenance & Evidence